Dan Jacobson’s career as a computational systems biologist has included leadership roles in academic, corporate, NGO and national lab settings. His lab focuses on the development and subsequent application of computational methods to biological datasets. These methods are applied to various population-scale multiomics data sets in an attempt to better understand the functional relationships at play in biological organisms and communities. His group at ORNL studies many systems - from viruses to microbes to plants to Drosophila, mice and humans. His lab is actively involved in the development of new exascale applications for biology and he is a recent recipient of the Gordon Bell Prize.