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DTSTAMP:20190719T085744Z
LOCATION:HG E 3
DTSTART;TZID=Europe/Stockholm:20190613T174500
DTEND;TZID=Europe/Stockholm:20190613T181500
UID:submissions.pasc-conference.org_PASC19_sess113_msa240@linklings.com
SUMMARY:Numerical Modelling of Epithelial Tissues: Mechanics and Morphogen
 esis
DESCRIPTION:Minisymposium\nComputer Science and Applied Mathematics, Physi
 cs, Life Sciences\n\nNumerical Modelling of Epithelial Tissues: Mechanics 
 and Morphogenesis\n\nMerzouki, Chopard\n\nIn this presentation, we introdu
 ce our numerical model of cell monolayers and its application to study the
  interplay between cell biophysical properties, and tissue mechanics and m
 orphology. Our cell-based model combines cell physics and biology; it incl
 udes the representation of cell mechanical properties, the application of 
 external mechanical constraints, and the simulation of cell proliferation 
 and signaling. This model was inspired from the vertex model of Farhadifar
  et al. 2007, which we adapted and progressively extended within our EpiCe
 lls framework (www.epicells.unige.ch). In particular, we present how this 
 model allowed us to investigate the effect of cell mechanical properties o
 n the response of tissues to stretching; we compared our simulations of ti
 ssue stretching to the experiments of Harris et al. 2012, which we used to
  calibrate our model. The calibration results suggested how cell mechanica
 l properties should adjust to tissue stretching in order to match the mech
 anics of cultured epithelium. Finally, we show how we used this vertex mod
 el to study tissue buckling. In the context of our collaboration with the 
 Roux Lab (University of Geneva) where epithelial cell monolayers are cultu
 red inside hydrogel microcapsules, we investigated the folding of simulate
 d tissue cross-sections growing under the constraints of an elastic enviro
 nment.
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